Interleukin gene polymorphisms in Chinese Han population with breast cancer, a case-control study

作者：Xiaoxiao Zuo, Miao Li, Ya Yang, Tiansong Liang, Hongyao Yang, Xinhan Zhao, Daoke Yang · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.23157 · 被引用次数：20 · 研究领域：IL-33, ST2, and ILC Pathways、Immune Cell Function and Interaction、Inflammasome and immune disorders

// Xiaoxiao Zuo 1, * , Miao Li 2, * , Ya Yang 1 , Tiansong Liang 1 , Hongyao Yang 1 , Xinhan Zhao 2 and Daoke Yang 1 1 Department of Radiation Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province 450000, People's Republic of China 2 Department of Internal Medicine Oncology, The Fifth People’s Hospital of Qinghai Province, Xining, Qinghai 810007, China * These authors contribute equally to this work Correspondence to: Daoke Yang, email: ydk8666@126.com Xinhan Zhao, email: zhaoxinhan@mail.xjtu.edu.cn Keywords: cytokines; IL1; breast cancer; case-control; polymorphisms Received: September 06, 2017      Accepted: November 15, 2017      Epub: December 11, 2017      Published: April 06, 2018 ABSTRACT Cytokines are known as important regulators of the cancer involved in inflammatory and immunological responses. This fact and plethora of gene polymorphism data prompted us to investigate IL1 gene polymorphisms in breast cancer (BC) patients. Totally, 530 patients with BC and 628 healthy control women were studied. The genetic polymorphisms for IL1 were analyzed by Massarray Sequencing method. Three single nucleotide polymorphisms (SNPs) identified in IL1B, IL1R1 gene are thought to influence breast cancer risk. The results of the association between IL-1B, IL1R1 polymorphisms and breast cancer risk have significant. We found that the variant TT genotype of rs10490571 was ...