Strigolactones: a plant phytohormone as novel anti-inflammatory agents

作者：Junxia Zheng, Yushui Han, Jincai Wang, Hui Yang, Hao Kong, Kang-Jia Liu, Siyu Chen, Yirui Chen, Yiqun Chang, Wei‐Min Chen, Jialiang Guo, Pinghua Sun · 发表于：MedChemComm · 年份：2017 · DOI：10.1039/c7md00461c · 被引用次数：21 · 研究领域：Plant Parasitism and Resistance、Plant and animal studies、Plant-derived Lignans Synthesis and Bioactivity

) demonstrated strong inhibitory activity on the release of inflammatory cytokines, including nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) by blocking the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways; they also greatly inhibited the migration of neutrophils and macrophages in fluorescent protein labeled zebrafish larvae. These results identified the promising anti-inflammatory effects of SLs, and suggested that both the absolute configuration of SL and the α,β-unsaturated D-ring structure are essential for the observed anti-inflammatory activity.