Co-delivery nanoparticles of anti-cancer drugs for improving chemotherapy efficacy

作者：Shanshan Qi, Jia-Hui Sun, Hao-Han Yu, Shuqin Yu · 发表于：Drug Delivery · 年份：2017 · DOI：10.1080/10717544.2017.1410256 · 被引用次数：215 · 研究领域：Nanoparticle-Based Drug Delivery、Drug Transport and Resistance Mechanisms、RNA Interference and Gene Delivery

To achieve superior therapeutic efficacy, the combination chemotherapy using two or more anticancer drugs in clinical practice has been generally accepted as a feasible strategy. On account of the concept of combination chemotherapy, co-delivery of anticancer drugs with nanotechnology gradually becomes a desired strategy and one of the research frontiers on modern drug delivery. In recent years, nano drug co-delivery system (NDCDS), which loads at least two anticancer drugs with different physicochemical and pharmacological properties into a combination delivery system, has achieved rapid development. NDCDS synergistically inhibited the growth of the tumor compared with the free drugs. In this review, we highlighted the current state of co-delivery nanoparticles and the most commonly used nanomaterial, discussed challenges and strategies, and prospect future development.