Differential Modulating Effect of MoS 2 on Amyloid Peptide Assemblies

作者：Jie Wang, Lei Liu, Daohan Ge, Hong‐Xing Zhang, Yonghai Feng, Yibang Zhang, Menglin Chen, Mingdong Dong · 发表于：Chemistry - A European Journal · 年份：2017 · DOI：10.1002/chem.201704593 · 被引用次数：35 · 研究领域：Supramolecular Self-Assembly in Materials、Advanced biosensing and bioanalysis techniques、RNA Interference and Gene Delivery

Abstract The abnormal fibrillogenesis of amyloid peptides such as amyloid fibril and senior amyloid plaques, is associated with the pathogenesis of many amyloid diseases. Hence, modulation of amyloid assemblies is related to the possible pathogenesis of some diseases. Some two‐dimensional nanomaterials, that is, graphene oxide, tungsten disulfide, exhibit strong modulation effects on the amyloid fibrillogenesis. Herein, the modulation effect of molybdenum disulfide on two amyloid peptide assemblies based on the label‐free techniques is presented, including quartz crystal microbalance (QCM), AFM, and CD spectroscopy. MoS 2 presents different modulating effects on the assembly of amyloid‐β peptide (33–42) [Aβ (33–42)] and amylin (20–29), mainly owing to the distinct affinity between amyloid peptides and MoS 2 . This is to our knowledge the first report of MoS 2 as a modulator for amyloid aggregation. It enriches the variety of 2D nanomodulators of amyloid fibrillogenesis and explains the mechanism for the self‐assembly of amyloid peptides, and expands the applications of MoS 2 in biology.