Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer

作者：Fangfang Cai, Minghui Chen, Daolong Zha, Peng Zhang, Xiangyu Zhang, Nini Cao, Jishuang Wang, Yan He, Xinxin Fan, Wenjing Zhang, Zhongping Fu, Yueyang Lai, Zi‐Chun Hua, Hongqin Zhuang · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.23308 · 被引用次数：53 · 研究领域：Inflammatory mediators and NSAID effects、Synthesis and biological activity、Estrogen and related hormone effects

// Fangfang Cai 1, * , Minghui Chen 1, 2, * , Daolong Zha 1 , Peng Zhang 2 , Xiangyu Zhang 1 , Nini Cao 1 , Jishuang Wang 2 , Yan He 2 , Xinxin Fan 2 , Wenjing Zhang 2 , Zhongping Fu 2 , Yueyang Lai 1, 3 , Zi-Chun Hua 1, 2 and Hongqin Zhuang 1 1 The State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China 2 State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China 3 Nanjing Industrial Innovation Center for Pharmaceutical Biotechnology, Nanjing, China * These authors have contributed equally to this work Correspondence to: Hongqin Zhuang, email: hqzhuang@nju.edu.cn Zi-Chun Hua, email: hzc1117@nju.edu.cn Keywords: celecoxib; curcumol; synergism; apoptosis; tumor metastasis Received: August 16, 2017      Accepted: December 05, 2017      Published: December 14, 2017 ABSTRACT Combinatorial therapies that target multiple signaling pathways may provide improved therapeutic responses over monotherapies. Celecoxib and curcumol are two highly hydrophobic drugs which show bioavailability problems due to their poor aqueous solubility. In the present study, we evaluated the effects of celecoxib and curcumol alone and in combination on cell proliferation, invasion, migration, cell cycle and apoptosis induction in non-small cell lung cancer (NSCLC) cells using in vitro and in vivo experiments. Our data showed that the sensit...