Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

作者：Anna Mae Diehl, Christopher Paul Day · 发表于：New England Journal of Medicine · 年份：2017 · DOI：10.1056/nejmra1503519 · 被引用次数：1328 · 研究领域：Liver Disease Diagnosis and Treatment、Diet, Metabolism, and Disease、Lipid metabolism and disorders

Nonalcoholic steatohepatitis is a major cause of cirrhosis and liver cancer. It is associated with visceral adiposity and the metabolic syndrome and is nearly as common as type 2 diabetes. Metabolic stress, inflammation, and fibrosis are the primary pathogenic mechanisms.