Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity

作者：Houjun Xia, Wei Wang, Joel Crespo, Ilona Kryczek, Wei Li, Shuang Wei, Zhaoqun Bian, Tomasz Maj, Ming‐Xiao He, J Rebecca Liu, You‐Wen He, Ramandeep Rattan, Adnan Munkarah, Jun‐Lin Guan, Weiping Zou · 发表于：Science Immunology · 年份：2017 · DOI：10.1126/sciimmunol.aan4631 · 被引用次数：151 · 研究领域：Immunotherapy and Immune Responses、Immune Cell Function and Interaction、Phagocytosis and Immune Regulation

Tumor-derived lactate induced naïve T cell apoptosis via suppressing FIP200 expression and autophagy formation, resulting in mitochondria activation and imbalance of Bcl-2 family members in T cells.