Aging of hematopoietic stem cells

作者：Gerald de Haan, Seka Lazare · 发表于：Blood · 年份：2017 · DOI：10.1182/blood-2017-06-746412 · 被引用次数：454 · 研究领域：Hematopoietic Stem Cell Transplantation、Acute Myeloid Leukemia Research、Immune cells in cancer

Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas the occurrence of cellular derailment strongly increases. Here we review our current understanding of the molecular mechanisms that contribute to HSC aging. We argue that most of the causes that underlie HSC aging result from cell-intrinsic pathways, and reflect on which aspects of the aging process may be reversible. Because many hematological pathologies are strongly age-associated, strategies to intervene in aspects of the stem cell aging process may have significant clinical relevance.