Nickel‐Catalyzed Difluoromethylation of Arylboronic Acids with Bromodifluoromethane

作者：Xia‐Ping Fu, Yu‐Lan Xiao, Xingang Zhang · 发表于：Chinese Journal of Chemistry · 年份：2017 · DOI：10.1002/cjoc.201700624 · 被引用次数：59 · 研究领域：Fluorine in Organic Chemistry、Inorganic Fluorides and Related Compounds

Although bromodifluoromethane (BrCF 2 H) is a simple and readily available fluorine source, direct formation of difluoromethylated arenes with BrCF 2 H has not been reported. Herein, we describe an efficient method to access difluoromethylated arenes through a nickel‐catalyzed difluoromethylation of arylboronic acids with BrCF 2 H. The reaction exhibits high efficiency, good functional group tolerance and broad substrate scope, thus providing an efficient route for applications in drug discovery and development. Preliminary mechanistic studies reveal that a difluoromethyl radical is involved in the reaction.