Identification of a three miRNA signature as a novel potential prognostic biomarker in patients with bladder cancer

作者：Fei Peng, Hui Li, Hailang Xiao, Ling Li, Yan Li, Yi Wu · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.22318 · 被引用次数：16 · 研究领域：Bladder and Urothelial Cancer Treatments、Cancer-related molecular mechanisms research、MicroRNA in disease regulation

// Fei Peng 1, * , Hui Li 2, * , Hailang Xiao 3 , Ling Li 3 , Yan Li 4 and Yi Wu 1 1 Department of Laboratory, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People’s Hospital, Changsha, China 2 Reproductive Department, Xiangya Hospital, Central South University, Changsha, China 3 Nephrology Department, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People’s Hospital, Changsha, China 4 Department of Paediatrics, The First Affiliated Hospital of Hunan Normal University, Hunan Provincial People’s Hospital, Changsha, China * These authors have contributed equally to this work Correspondence to: Yi Wu, email: wuyi19701210@outlook.com Keywords : BLCA; miRNA; prognosis; biomarker; TCGA Received: November 23, 2016      Accepted: June 20, 2017      Published: November 06, 2017 ABSTRACT There is not a good biomaker that is closely related to survival time for bladder cancer(BLCA), The aim of the study is to identify a miRNA signature that could predict prognosis in BLCA patients according to the data from The Cancer Genome Atlas (TCGA). a total of 377 BLCA patients were finally enrolled in the study. The three miRNA signature was identified by Multivariate Cox proportional hazards analyses that common clinical variables were controled. The three microRNA signature showed greater predicting prognosis capacity for predicting 5-year survival in BLCA with an AUC of 0...