Cause-specific life-years lost in people with mental disorders: a nationwide, register-based cohort study

作者：Annette Erlangsen, Per Kragh Andersen, Anita Toender, Thomas Munk Laursen, Merete Nordentoft, Vladimir Canudas‐Romo · 发表于：The Lancet Psychiatry · 年份：2017 · DOI：10.1016/s2215-0366(17)30429-7 · 被引用次数：173 · 研究领域：Schizophrenia research and treatment、Mental Health Treatment and Access、Suicide and Self-Harm Studies

BACKGROUND: People with mental disorders have higher mortality rates than the general population and more detailed estimates of mortality differences are needed to address this public health issue. We aimed to assess whether differences in cause-specific mortality between people with and without mental disorders have changed between 1995 and 2014 by quantifying life-years lost and assessing differences over time. METHODS: Using a cohort design, we linked nationwide population data from the Danish Civil Registration System to information about hospital contacts from the Psychiatric Central Research Register and deaths from the Danish Cause of Death register. All linked data sources contained longitudinal information covering all individuals aged 15-94 years living in Denmark between 1995 and 2014. We assessed cause-specific mortality differences using rate ratios and average life-years lost. FINDINGS: Between 1995 and 2014, 6 107 234 individuals (3 026 132 men and 3 081 102 women) aged 15-94 years were living in Denmark. The study population was observed over 89 216 177 person-years (men: 43 914 948; women 45 301 229). Cause-specific mortality rates were higher for people with mental disorders than those without (total mortality rate per 1000 person-years in men 27·1 vs 11·4, respectively, and in women 21·2 vs 11·0). When compared with individuals without mental disorders, men and women with mental disorders had 10·20 and 7·34 excess life-years lost, respectively. The largest ...