Sorcin induces gastric cancer cell migration and invasion contributing to STAT3 activation

作者：Huan Tuo, Feng Shu, Sha She, Min Yang, Xiao Qin Zou, Juan Huang, Huai Dong Hu, Peng Hu, Hong Ren, Peng Shi, Yi Yang · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.22208 · 被引用次数：34 · 研究领域：Synthesis of Organic Compounds、Bioactive Compounds and Antitumor Agents、Bioactive natural compounds

// Huan Tuo 1, * , Feng Shu 1, * , Sha She 1 , Min Yang 1 , Xiao Qin Zou 1 , Juan Huang 1 , Huai Dong Hu 1, 2 , Peng Hu 1, 2, 3 , Hong Ren 1, 2, 3 , Shi Fang Peng 4, 5 and Yi Xuan Yang 1, 2, 3 1 Department of Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China 2 Institute for Viral Hepatitis of Chongqing Medical University, Chongqing 400016, China 3 Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Chongqing Medical University, Chongqing 400016, China 4 Department of Infectious Diseases, Xiangya Hospital, Central South University, Hunan 410008, China 5 Department of Health Management Center, Xiangya Hospital, Central South University, Hunan 410008, China * These authors have contributed equally to this work Correspondence to: Yi Xuan Yang, email: yxyangooo@sohu.com Shi Fang Peng, email: sfp1988@csu.edu.cn Keywords: gastric cancer (GC); sorcin; migration; invasion; iTRAQ Received: July 08, 2017      Accepted: September 21, 2017      Published: October 31, 2017 ABSTRACT Gastric cancer (GC) is a globally occurring malignancy that is characterized by a high mortality rate due to a high tendency to metastasize and poor prognoses. Sorcin, as known as SRI, a soluble resistance-related calcium-binding protein, plays a significant role in multidrug resistance. Sorcin is related to the migration and invasion of cancer cells. However, the mechanism...