Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in Invasive Breast Carcinoma and Ductal Carcinoma In Situ, Metastatic Tumor Deposits and Areas for Further Research

作者：Shona A. Hendry, Roberto Salgado, Thomas Gevaert, Prudence Anne Russell, Tom John, Bibhusal Thapa, Michael Christie, Koen K Van de Vijver, Monica Valeria Estrada, Paula I. González-Ericsson, Melinda E. Sanders, Benjamin J. Solomon, Cinzia Solinas, Gert G. G. M. Van den Eynden, Yves Allory, Matthias Preusser, Johannes Andreas Hainfellner, Giancarlo Pruneri, Andrea Vingiani, Sandra Demaria, Fraser W. Symmans, Paolo Giovanni Nuciforo, Laura Comerma, E. Aubrey Thompson, Sunil R. Lakhani, Seong-Rim Kim, Stuart J. Schnitt, Cécile Colpaert, Christos P. Sotiriou, Stefan J. Scherer, Michail Ignatiadis, Sunil Badve, Robert Hamilton Pierce, Giuseppe Viale, Nicolas Sirtaine, Frédérique Penault‐Llorca, Tomohagu Sugie, Susan Fineberg, Soonmyung Paik, Ashok Srinivasan, Andrea L. Richardson, Yihong Wang, Ewa Chmielik, Jane B. Brock, Douglas Buckner Johnson, Justin Micah Balko, Stephan Wienert, Veerle Bossuyt, Stefan Michiels, Nils Ternès, Nicole Burchardi, Stephen James Luen, Peter Savas, Frederick Klauschen, Peter Hamilton Watson, Brad H. Nelson, Carmen Criscitiello, Sandra A. O’Toole, Denis Larsimont, Roland de Wind, Giuseppe Curigliano, Fabrice André, Magali Lacroix‐Triki, Marc J. van de Vijver, Federico Rojo, Giuseppe Floris, Shahinaz Ahmed Bedri, Joseph A. Sparano, David L. Rimm, Torsten O. Nielsen, Zuzana Kos, Stephen M. Hewitt, Baljit Singh, Gelareh Farshid, Sibylle Loibl, Kimberly H. Allison, Nadine Tung, Sylvia Adams, Karen E Willard-Gallo, Hugo M. Horlings, Leena Gandhi, Andre Luis Moreira, Fred R. Hirsch, Maria Vittoria Dieci, María Urbanowicz, Iva Brčić, Konstanty Korski, Fabien Gaire, Hartmut Koeppen, Amy Lo, Jennifer Margaret Giltnane, Marlon Cezar Rebelatto, Keith E. Steele, Jiping Zha, Kenneth Emancipator, Jonathan Wes Juco, Carsten Denkert, Jorge Sergio Reis-Filho, Sherene Loi, Stephen B. Fox · 发表于：Advances in Anatomic Pathology · 年份：2017 · DOI：10.1097/pap.0000000000000162 · 被引用次数：739 · 研究领域：Cancer Immunotherapy and Biomarkers、Immunotherapy and Immune Responses、Immune Cell Function and Interaction

Assessment of tumor-infiltrating lymphocytes (TILs) in histopathologic specimens can provide important prognostic information in diverse solid tumor types, and may also be of value in predicting response to treatments. However, implementation as a routine clinical biomarker has not yet been achieved. As successful use of immune checkpoint inhibitors and other forms of immunotherapy become a clinical reality, the need for widely applicable, accessible, and reliable immunooncology biomarkers is clear. In part 1 of this review we briefly discuss the host immune response to tumors and different approaches to TIL assessment. We propose a standardized methodology to assess TILs in solid tumors on hematoxylin and eosin sections, in both primary and metastatic settings, based on the International Immuno-Oncology Biomarker Working Group guidelines for TIL assessment in invasive breast carcinoma. A review of the literature regarding the value of TIL assessment in different solid tumor types follows in part 2. The method we propose is reproducible, affordable, easily applied, and has demonstrated prognostic and predictive significance in invasive breast carcinoma. This standardized methodology may be used as a reference against which other methods are compared, and should be evaluated for clinical validity and utility. Standardization of TIL assessment will help to improve consistency and reproducibility in this field, enrich both the quality and quantity of comparable evidence, and hel...