Genetic variations of NTCP are associated with susceptibility to HBV infection and related hepatocellular carcinoma

作者：Peng Wang, Ruidong Mo, Rongtao Lai, Yumin Xu, Jie Lu, Gangde Zhao, Yuhan Liu, Zhujun Cao, Xiaolin Wang, Ziqiang Li, Lanyi Lin, Huijuan Zhou, Wei Cai, Hui Wang, Shisan Bao, Xiaogang Xiang, Qing Xie · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.22211 · 被引用次数：29 · 研究领域：Hepatitis B Virus Studies、Drug Transport and Resistance Mechanisms、Liver Disease Diagnosis and Treatment

// Peng Wang 1, 2, * , Ruidong Mo 1, 2, * , Rongtao Lai 1, 2, * , Yumin Xu 1, 2 , Jie Lu 2 , Gangde Zhao 1, 2 , Yuhan Liu 1, 2 , Zhujun Cao 1, 2 , Xiaolin Wang 1, 2 , Ziqiang Li 1, 2 , Lanyi Lin 1 , Huijuan Zhou 1 , Wei Cai 1 , Hui Wang 1 , Shisan Bao 1, 3 , Xiaogang Xiang 1, 2 and Qing Xie 1, 2 1 Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 2 Translational Lab of Liver Diseases, Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China 3 Discipline of Pathology, School of Medical Sciences and Bosch Institute, The University of Sydney, New South Wales 2006, Australia * These authors have contributed equally to this work Correspondence to: Qing Xie, email: xieqingrjh@163.com Xiaogang Xiang, email: shine-xxg@163.com Keywords: Na + taurocholate cotransporting polypeptide; association study; HBV; HCC; meta-analysis Received: July 19, 2017      Accepted: September 21, 2017      Published: October 31, 2017 ABSTRACT Sodium taurocholate cotransporting polypeptide (NTCP), encoded by gene SLC10A1, is a receptor for hepatitis B virus (HBV). The aim of the current study was to investigate the role of NTCP polymorphisms in HBV susceptibility, cirrhosis and hepatocarcinogenesis. A total 1221 cases [including 866 chronic hepatitis B (CHB), 238 liver cirrhosis (LC), 117 hepatocellular carcinoma (HCC) patients] and...