Re-Establishing Brain Networks in Patients with ESRD after Successful Kidney Transplantation

作者：Huijuan Chen, Jiqiu Wen, Rongfeng Qi, Jianhui Zhong, U. Joseph Schoepf, Ákos Varga‐Szemes, Virginia W. Lesslie, Xiang Kong, Yun Fei Wang, Qiang Xu, Zhe Zhang, Xue Li, Guangming Lu, Long Jiang Zhang · 发表于：Clinical Journal of the American Society of Nephrology · 年份：2017 · DOI：10.2215/cjn.00420117 · 被引用次数：34 · 研究领域：Functional Brain Connectivity Studies、Dialysis and Renal Disease Management、Epilepsy research and treatment

BACKGROUND AND OBJECTIVES: Cognition in ESRD may be improved by kidney transplantation, but mechanisms are unclear. We explored patterns of resting-state networks with resting-state functional magnetic resonance imaging among patients with ESRD before and after kidney transplantation. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Thirty-seven patients with ESRD scheduled for kidney transplantation and 22 age-, sex-, and education-matched healthy subjects underwent resting-state functional magnetic resonance imaging. Patients were imaged before and 1 and 6 months after kidney transplantation. Functional connectivity of seven resting-state subnetworks was evaluated: default mode network, dorsal attention network, central executive network, self-referential network, sensorimotor network, visual network, and auditory network. Mixed effects models tested associations of ESRD, kidney transplantation, and neuropsychological measurements with functional connectivity. RESULTS: =0.01). Six months after kidney transplantation, no significant difference in functional connectivity was observed for the dorsal attention network, the central executive network, the auditory network, or the visual network between patients and controls. Default mode network and sensorimotor network remained significantly different from those in controls when assessed 6 months after kidney transplantation. A relationship between functional connectivity and neuropsychological measurements was found in specific b...