Biomimetic inorganic camouflage circumvents antibody-dependent enhancement of infection

作者：Xiaoyu Wang, Yong‐Qiang Deng, Dong Yang, Yun Xiao, Hui Zhao, Qing-Gong Nian, Xurong Xu, Xiaofeng Li, Ruikang Tang, Cheng‐Feng Qin · 发表于：Chemical Science · 年份：2017 · DOI：10.1039/c7sc03868b · 被引用次数：21 · 研究领域：Nanoplatforms for cancer theranostics、Polydiacetylene-based materials and applications、Advanced Nanomaterials in Catalysis

. Moreover, the nanoshell can spontaneously degrade under intracellular conditions to restore the virus activity and immunogenicity due to its pH-sensitive behaviour. This work demonstrates that the biomimetic material shell can significantly improve the administration safety and potency of the DENV vaccine, which provides the promising prospect of chemically designed virus-material hybrids for immune evasion.