Food groups and risk of coronary heart disease, stroke and heart failure: A systematic review and dose-response meta-analysis of prospective studies

作者：Angela Bechthold, Heiner Boeing, Carolina Schwedhelm, Georg Hoffmann, Sven Knüppel, Khalid Iqbal, Stefaan De Henauw, Nathalie Michels, Brecht Devleesschauwer, Sabrina Schlesinger, Lukas Schwingshackl · 发表于：Critical Reviews in Food Science and Nutrition · 年份：2017 · DOI：10.1080/10408398.2017.1392288 · 被引用次数：714 · 研究领域：Nutritional Studies and Diet、Nuts composition and effects、Antioxidant Activity and Oxidative Stress

Background: Despite growing evidence for food-based dietary patterns' potential to reduce cardiovascular disease risk, knowledge about the amounts of food associated with the greatest change in risk of specific cardiovascular outcomes and about the quality of meta-evidence is limited. Therefore, the aim of this meta-analysis was to synthesize the knowledge about the relation between intake of 12 major food groups (whole grains, refined grains, vegetables, fruits, nuts, legumes, eggs, dairy, fish, red meat, processed meat, and sugar-sweetened beverages [SSB]) and the risk of coronary heart disease (CHD), stroke and heart failure (HF).Methods: We conducted a systematic search in PubMed and Embase up to March 2017 for prospective studies. Summary risk ratios (RRs) and 95% confidence intervals (95% CI) were estimated using a random effects model for highest versus lowest intake categories, as well as for linear and non-linear relationships.Results: Overall, 123 reports were included in the meta-analyses. An inverse association was present for whole grains (RRCHD: 0.95 (95% CI: 0.92–0.98), RRHF: 0.96 (0.95–0.97)), vegetables and fruits (RRCHD: 0.97 (0.96–0.99), and 0.94 (0.90–0.97); RRstroke: 0.92 (0.86–0.98), and 0.90 (0.84–0.97)), nuts (RRCHD: 0.67 (0.43–1.05)), and fish consumption (RRCHD: 0.88 (0.79–0.99), RRstroke: 0.86 (0.75–0.99), and RRHF: 0.80 (0.67–0.95)), while a positive association was present for egg (RRHF: 1.16 (1.03–1.31)), red meat (RRCHD: 1.15 (1.08–1.23), RRstro...