LncRNA TUG1 sponges miR-145 to promote cancer progression and regulate glutamine metabolism via Sirt3/GDH axis

作者：Bing Zeng, Huilin Ye, Jianming Chen, Di Cheng, Canfeng Cai, Guoxing Chen, Xiang Chen, Haiyang Xin, Chaoming Tang, Jun Zeng · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.21922 · 被引用次数：90 · 研究领域：Cancer-related molecular mechanisms research、Cholangiocarcinoma and Gallbladder Cancer Studies、RNA modifications and cancer

// Bing Zeng 1, 2, * , Huilin Ye 1, * , Jianming Chen 3, * , Di Cheng 4 , Canfeng Cai 2 , Guoxing Chen 2 , Xiang Chen 2 , Haiyang Xin 2 , Chaoming Tang 2 and Jun Zeng 2 1 Department of Hepatopancreatobiliary Surgery, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China 2 Department of Gastrointestinal Surgery, The Sixth Affiliated Hospital of Guangzhou Medical University, Qing Yuan People’s Hospital, Guangdong 511518, China 3 Department of Gastroenterology, The 251st Hospital of PLA, Zhangjiakou 075000, China 4 Department of Gastroenterology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, China * These authors have contributed equally to this work Correspondence to: Jun Zeng, email: zengjun2017@126.com Chaoming Tang, email: chaomingtt001@163.com Keywords: TUG1; intrahepatic cholangiocarcinoma; miR-145; glutamine metabolism; Sirt3 Received: June 14, 2017     Accepted: September 08, 2017     Published: October 19, 2017 ABSTRACT Long noncoding RNAs (lncRNAs) are important regulators in cancer progression. Deregulation of the lncRNA taurine upregulated gene 1 (TUG1) predicts poor prognosis and is implicated in the development of several cancers. In this study, we investigated the role of TUG1 in the pathogenesis of intrahepatic cholangiocarcinoma (ICC). We found that TUG1 is upregulated in ICC samples, which correlates with poor prognosis and adverse clinical pathological charact...