P2 Purinoceptors: Historical Perspective and Classification

作者：Geoff Burnstock · 发表于：Novartis Foundation symposium · 年份：2007 · DOI：10.1002/9780470514900.ch1 · 被引用次数：143 · 研究领域：Adenosine and Purinergic Signaling、Neuroscience of respiration and sleep、Receptor Mechanisms and Signaling

This article presents an overview that gives some historical perspective to the detailed papers at the cutting edge of P2 purinoceptor research that follow. I consider the proposal, first put forward by Abbracchio & Burnstock (Pharmacol Ther 64:445-475, 1994), that P2 purinoceptors should be regarded as members of two main families: a P2X purinoceptor family consisting of ligand-gated ion channels, and a P2Y purinoceptor family consisting of G protein-coupled receptors. The latest subclasses of these two families (P2X1-4 and P2Y1-5), identified largely on the basis of molecular cloning and expression, are tabled. Finally, I suggest some future directions for P2 purinoceptor research, including studies of the long-term (trophic) actions of purines, the evolution and development of purinoceptors and therapeutic applications.