Association of fibroblast growth factor receptor 1 gene amplification with poor survival in patients with esophageal squamous cell carcinoma

作者：Dong Wang, Licheng Du, Zhou Wang, Xiangyan Liu, Yejun Qin, Qiangxiu Wang, Zhe Yang, Zhigang Yao, Mo Shi, Bin Shang, Yang Jia, Huaxia Chen, Liang Qiao, Xueqing Wang, Zhaohua Xiao, Zhenchuan Liu · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.21486 · 被引用次数：11 · 研究领域：Fibroblast Growth Factor Research、Esophageal Cancer Research and Treatment、Bladder and Urothelial Cancer Treatments

// Dong Wang 1 , Licheng Du 2 , Zhou Wang 1 , Xiangyan Liu 1 , Yejun Qin 3 , Qiangxiu Wang 3 , Zhe Yang 4 , Zhigang Yao 3 , Mo Shi 1 , Bin Shang 1 , Yang Jia 1 , Huaxia Chen 1 , Liang Qiao 1 , Xueqing Wang 1 , Zhaohua Xiao 1 and Zhenchuan Liu 1 1 Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China 2 Department of General Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China 3 Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China 4 Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China Correspondence to: Zhou Wang, email: wz620226@hotmail.com Keywords: esophageal neoplasms, survival analysis, receptor, fibroblast growth factor, type 1 Received: July 21, 2017      Accepted: August 27, 2017      Published: October 04, 2017 ABSTRACT Purpose : To investigate whether FGFR1 gene amplification is associated with clinicopathologic characteristics and its potential impact on survival in patients with resected esophageal squamous cell carcinoma (ESCC). Methods : Five hundred fifty-six ESCC patients undergoing curative resection of ESCC were retrospectively studied. FGFR1 gene copy number was determined in microarrayed tumor samples using fluorescent in situ hybridization (FISH) analysis. FGFR1 gene amplification status was prespecified as copy number ≥ 6 ...