Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice

作者：Haobin Cai, Yijie Wang, Jiayang He, Tiantian Cai, Jun Wu, Jiansong Fang, Rong Zhang, Zhouke Guo, Li Guan, Qinkai Zhan, Lin Li, Yao Xiao, Huafeng Pan, Qi Wang · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.21515 · 被引用次数：22 · 研究领域：Medicinal Plants and Neuroprotection、Alzheimer's disease research and treatments、Neuroinflammation and Neurodegeneration Mechanisms

// Haobin Cai 2, 1 , Yijie Wang 1 , Jiayang He 1 , Tiantian Cai 1 , Jun Wu 1 , Jiansong Fang 1 , Rong Zhang 1 , Zhouke Guo 2 , Li Guan 1 , Qinkai Zhan 1 , Li Lin 3 , Yao Xiao 4 , Huafeng Pan 1 and Qi Wang 1 1 Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China 2 Department of Neurology & Psychology, Shenzhen Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine, Shenzhen 518033, China 3 Guangzhou University of Chinese Medicine, Guangzhou 510405, China 4 Guangzhou Medical University, Guangzhou 510182, China Correspondence to: Qi Wang, email: wangqi@gzucm.edu.cn Huafeng Pan, email: gzphf@126.com Keywords: dementia, bajijiasu, amyloid-β, cognitive impairment, APP/PS1 mice Received: July 13, 2017      Accepted: September 03, 2017      Published: October 04, 2017 ABSTRACT Alzheimer's disease (AD) is a progressive neurological degenerative disease. The main clinical manifestations of AD include progressive cognitive impairment and alteration of personality. Senile plaques, neuroinflammation, and destruction of synapse structure stability are the main pathological features of AD. Bajijiasu(BJJS) is extracted from Morinda Officinalis, a Chinese herb. In this study, we explored the effect of BJJS on AD from many aspects in APPswe/PSEN1ΔE9 (APP/PS1) double transgenic mice. The Morris water maze and novel object recognition tests results showed tha...