Dual enhancement of T and NK cell function by pulsatile inhibition of SHIP1 improves antitumor immunity and survival

作者：Matthew Gumbleton, Raki Sudan, Sandra Fernandes, Robert W. Engelman, Christopher M. Russo, John D. Chisholm, William G. Kerr · 发表于：Science Signaling · 年份：2017 · DOI：10.1126/scisignal.aam5353 · 被引用次数：49 · 研究领域：Immune Cell Function and Interaction、T-cell and B-cell Immunology、Galectins and Cancer Biology

T cells in vitro and in vivo. Transient SHIP1 inhibition in mouse models of lymphoma and colon cancer improved the median and long-term tumor-free survival rates. Adoptive transfer assays showed evidence of immunological memory to the tumor in hematolymphoid cells from SHIPi-treated, long-term surviving mice. The findings suggest that a pulsatile regimen of SHIP1 inhibition might be an effective immunotherapy in some cancer patients.