Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

作者：Xiangzhen Kong, Samuel R. Mathias, Tulio M. Guadalupe, ENIGMA Laterality Working Group, David C. Glahn, Barbara Franke, Fabrice Crivello, Nathalie Tzourio-Mazoyer, Simon E. Fisher, Paul M. Thompson, Clyde Francks, ENIGMA Laterality Working Group, Xiangzhen Kong, Samuel R. Mathias, Tulio M. Guadalupe, Christoph Abé, Ingrid Agartz, Theophilus N. Akudjedu, André Alemán, Saud Alhusaini, Nicholas Brian Allen, David Ames, Ole A. Andreassen, Alejandro Arias Vásquez, Nicola Jane Armstrong, Felipe P. G. Bergo, Mark E. Bastin, Albert Batalla, Jochen Bauer, Bernhard Theodor Baune, Ramona Baur‐Streubel, Joseph Biederman, Sara K. Blaine, Premika S.W. Boedhoe, Erlend Bøen, Anushree Bose, Janita Bralten, Daniel Brandeis, Silvia Brem, Henry Brodaty, Dilara Yüksel, Samantha Jane Brooks, Jan Buitelaar, Christian P. Burger, Robin Bülow, Vince D. Calhoun, Anna Calvo, Erick Jorge Canales-Rodríguez, José M. Cañive, Dara M. Cannon, Elisabeth C. Caparelli, F. Xavier Castellanos, Gianpiero L. Cavalleri, Fernando Cendes, Tiffany Moukbel Chaim-Avancini, Kaylita C. Chantiluke, Qunlin Chen, Xiayu S. Chen, Yuqi Cheng, Anastasia Christakou, Vincent P. Clark, David Coghill, Colm G. Connolly, Annette Conzelmann, Aldo Córdova‐Palomera, Janna Cousijn, Tim J. Crow, Ana Cubillo, Anders Martin Dale, Udo Dannlowski, Sara Ambrosino de Bruttopilo, Patrick de Zeeuw, Ian J. Deary, Norman Delanty, Damion V. Demeter, Adriana Di Martino, Erin W. Dickie, Bruno Dietsche, Nhat Trung Doan, Colin P. Doherty, Alysa E. Doyle, Sarah Durston, Eric A Earl, Stefan Ehrlich, Carl Johan Ekman, Torbjørn Elvsåshagen, Jeffery N. Epstein, Damien A. Fair, Stephen V. Faraone, Guillén Fernández, Geraldo F. Busatto, Katharina Förster, Jean‐Paul Fouché, John J. Foxe, Thomas Frodl, Paola Fuentes‐Claramonte, Janice M. Fullerton, Hugh P Garavan, Danielle do Santos Garcia, Ian H. Gotlib, Anna E. Goudriaan, Hans Jörgen Grabe, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Tiril Pedersen Gurholt, Jan Haavik, Tim Hahn, Narelle K. Hansell, Mathew A. Harris, Catharina Annette Hartman, María Valdés Hernández, Dirk J. Heslenfeld, Robert Hester, Derrek Paul Hibar, Beng‐Choon Ho, Tiffany Cheing Ho, Pieter J. Hoekstra, Ruth Janke van Holst, Martine Hoogman, Marie Farstad Høvik, Fleur Margaret Howells, Kenneth Hugdahl, Chaim Huyser, Martin Ingvar, Lourdes Irwin, Akari Ishikawa, Anthony James, Neda Jahanshad, Terry L. Jernigan, Erik Gunnar Jönsson, Claas Kähler, В. Г. Каледа, Clare A. M. Kelly, Michael J. Kerich, Matcheri S. Keshavan, Sabin Khadka, Tilo T. J. Kircher, Gregor Kohls, Kerstin Konrad, Ozlem Korucuoglu, Bernd Krämer, Axel Krug, Jun Soo Kwon, Nanda N. J. Lambregts-Rommelse, Mikael Landén, Luisa Lázaro, И. С. Лебедева, Rhoshel Lenroot, Klaus‐Peter Lesch, Qinqin Li, Kelvin O. Lim, Jia Liu, Christine Löchner, Edythe D. London, Vera Lonning, Valentina Lorenzetti, Michelle Luciano, Maartje Luijten, Astri Johansen Lundervold, Scott Mackey, Frank P. MacMaster, Sophie Maingault, Charles Benjamin Malpas, Ulrik Fredrik Malt, David Mataix‐Cols, Rocío Martín‐Santos, Andrew R. Mayer, Hazel McCarthy, Philip Bowden Mitchell, Bryon A. Mueller, Susana Muñoz Maniega, Bernard M. Mazoyer, Colm McDonald, Quinn McLellan, Katie Louise McMahon, Genevieve McPhilemy, Reza Momenan, Angelica M. Morales, Janardhanan C. Narayanaswamy, José Carlos Vasques Moreira, Stener Nerland, Liam J. Nestor, Erik R. Newman, Joel T. Nigg, Jan Egil Nordvik, Stephanie E. Novotny, Eileen Oberwelland Weiß, Ruth L. O’Gorman, Jaap Oosterlaan, Bob Oranje, Catherine Orr, Bronwyn J. Overs, Paul Pauli, Martin P. Paulus, Kerstin Jessica Plessen, Georg G. von Polier, Edith Pomarol‐Clotet, Marı́a J. Portella, Jiang Hua Qiu, Joaquim Raduà, Josep Antoni Ramos‐Quiroga, Y.C. Janardhan Reddy, Andreas Reif, Gloria M.P. Roberts, Pedro G. P. Rosa, Katya Rubia, Matthew D. Sacchet, Perminder Singh Sachdev, Raymond M. Salvador, Lianne Schmaal, Martin Schulte‐Rüther, Lizanne Schweren, Larry J. Seidman, Jochen Seitz, Maurício Henriques Serpa, Philip Shaw, Elena Shumskaya, Timothy J. Silk, Alan N. Simmons, Egle Simulionyte, Rajita Sinha, Zsuzsika Sjoerds, Runar Elle Smelror, Joan Carlos Soliva, Nadia Solowij, Fábio Duran, Scott R. Sponheim, Dan J. Stein, Elliot A. Stein, Michael C. G. Stevens, Lachlan T. Strike, Gustavo P. Sudre, Jing Sui （Beijing Normal University）， my correct affiliation is beijing normal university, not Qingdao University of Science and Technology, please correct the current affiliation. Thank you, Leanne Tamm, Hendrik S. Temmingh, Robert J. Thoma, Alexander S. Tomyshev, Giulia Tronchin, Jessica A. Turner, Anne Uhlmann, Theo G.M. van Erp, Odile A. van den Heuvel, Dennis van der Meer, Liza van Eijk, Alasdair L. A. Vance, Ilya Milos Veer, Dick J. Veltman, Ganesan Venkatasubramanian, Óscar Vilarroya, Yolanda Vives‐Gilabert, Aristotle N. Voineskos, Henry Völzke, Daniella Vuletic, Susanne Walitza, Henrik Walter, Esther Walton, Joanna Marguerite Wardlaw, Wei Wen, Lars Tjelta Westlye, Christopher D. Whelan, Tonya J.H. White, Reinout W. H. J. Wiers, Margaret J. Wright, Katharina Wittfeld, Tony T. Yang, Clarissa Lin Yasuda, Yuliya N. Yoncheva, Murat Yücel, Je‐Yeon Yun, Marcus V. Zanetti, Zonglei Zhen, Xingxing Zhu, Georg Christoph Ziegler, Kathrin C. Zierhut, Greig I. de Zubicaray, Marcel P. Zwiers, Karolinska Schizophrenia Project (KaSP), David C. Glahn, Barbara Franke, Fabrice Crivello, Nathalie Tzourio-Mazoyer, Simon E. Fisher, Paul M. Thompson, Clyde Francks, Lars Farde, Lena Flyckt, Göran Engberg, Sophie Erhardt, Helena Fatouros‐Bergman, Simon Červenka, Lilly Schwieler, Fredrik Piehl, Ingrid Agartz, Karin Collste, Pauliina Ikonen Victorsson, Anna Malmqvist, Mikael Hedberg, Funda Orhan · 发表于：Proceedings of the National Academy of Sciences · 年份：2018 · DOI：10.1073/pnas.1718418115 · 被引用次数：469 · 研究领域：Hemispheric Asymmetry in Neuroscience、Spatial Neglect and Hemispheric Dysfunction、Cognitive Abilities and Testing

Significance Left–right asymmetry is a key feature of the human brain's structure and function. It remains unclear which cortical regions are asymmetrical on average in the population and how biological factors such as age, sex, and genetic variation affect these asymmetries. Here, we describe by far the largest-ever study of cerebral cortical asymmetry, based on data from 17,141 participants. We found a global anterior–posterior “torque” pattern in cortical thickness, together with various regional asymmetries at the population level, which have not been previously described, as well as effects of age, sex, and heritability estimates. From these data, we have created an online resource that will serve future studies of human brain anatomy in health and disease.