MiR-195 suppresses the metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by inhibiting YAP

作者：Shuo Yu, Jing Li, Xiaoran Yin, Mincong Wang, Yimeng Chen, Ya Guo, Kejun Nan, Lili Han · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.20909 · 被引用次数：53 · 研究领域：Hippo pathway signaling and YAP/TAZ、MicroRNA in disease regulation、Cancer-related molecular mechanisms research

// Shuo Yu 3 , Li Jing 2 , Xiao-Ran Yin 1 , Min-Cong Wang 1 , Yi-Meng Chen 4 , Ya Guo 1 , Ke-Jun Nan 2 and Li-Li Han 1 1 Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province 710004, China 2 Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province 710061, China 3 Department of General Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province 710004, China 4 Department of Engineering Research Center of Bio-diagnosis and Biotherapy, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province 710004, China Correspondence to: Li-Li Han, email: 61439376@qq.com Keywords: hepatocellular carcinoma; microRNA; YAP; EMT Received: June 29, 2017     Accepted: August 08, 2017     Published: September 15, 2017 ABSTRACT MiR-195, a novel cancer-related microRNA, was previously reported to play an important role in many malignancies. This study aimed to investigate the role of miR-195 mediated epithelial–mesenchymal transition (EMT) and the progression of hepatocellular carcinoma (HCC) as well as the underlying mechanisms. Our result demonstrated that miR-195 were significantly down regulated in HCC and its decreased expression is associated with poor clinical features of HCC patients. Oppositely, expression level of YAP was significantl...