Smartphone based optical spectrometer for diffusive reflectance spectroscopic measurement of hemoglobin

作者：Perry S. Edwards, Chenji Zhang, Baigang Zhang, Xiangqian Hong, Vivek Krishna Nagarajan, Bing Yu, Zhiwen Liu · 发表于：Scientific Reports · 年份：2017 · DOI：10.1038/s41598-017-12482-5 · 被引用次数：103 · 研究领域：Optical Imaging and Spectroscopy Techniques、Non-Invasive Vital Sign Monitoring、Air Quality Monitoring and Forecasting

We report a miniature, visible to near infrared G-Fresnel spectrometer that contains a complete spectrograph system, including the detection hardware and connects with a smartphone through a microUSB port for operational control. The smartphone spectrometer is able to achieve a resolution of ~5 nm in a wavelength range from 400 nm to 1000 nm. We further developed a diffuse reflectance spectroscopy system using the smartphone spectrometer and demonstrated the capability of hemoglobin measurement. Proof of concept studies of tissue phantoms yielded a mean error of 9.2% on hemoglobin concentration measurement, comparable to that obtained with a commercial benchtop spectrometer. The smartphone G-Fresnel spectrometer and the diffuse reflectance spectroscopy system can potentially enable new point-of-care opportunities, such as cancer screening.