Association of adverse birth outcomes with prenatal exposure to vanadium: a population-based cohort study

作者：Jie Hu, Wei Xia, Xinyun Pan, Tongzhang Zheng, Bin Zhang, Aifen Zhou, Stephen L. Buka, Bryan A. Bassig, Wenyu Liu, Chuansha Wu, Peng Yang, Jun Li, Chuncao Zhang, Hongxiu Liu, Minmin Jiang, Youjie Wang, Jianduan Zhang, Zheng Huang, Dan Zheng, Kunchong Shi, Zhengmin Qian, Yuanyuan Li, Shunqing Xu · 发表于：The Lancet Planetary Health · 年份：2017 · DOI：10.1016/s2542-5196(17)30094-3 · 被引用次数：95 · 研究领域：Vanadium and Halogenation Chemistry、Organoselenium and organotellurium chemistry、Heavy Metal Exposure and Toxicity

BACKGROUND: Vanadium, an important pollutant produced from anthropogenic activities, has been suggested to be embryotoxic and fetotoxic in animal studies. However, little is known about its effects on humans. We aimed to assess the association of prenatal exposure to vanadium with the risk of adverse birth outcomes in babies born to women in China. METHODS: For this population-based cohort study, the Healthy Baby Cohort, women were recruited from three cities in Hubei Province, China. Women included in this analysis were recruited from Wuhan Women and Children Medical Care Center, Wuhan. We measured urinary concentrations of vanadium and other metals simultaneously using inductively coupled plasma mass spectrometry. We used multivariable logistic regressions, with adjustment for potential confounders, to estimate the associations of natural logarithm transformed creatinine-corrected urinary vanadium (Ln-vanadium) concentrations as continuous variables and categorised into quartiles (Q; Q1: ≤0·84 μg/g creatinine, Q2: 0·84-1·40 μg/g creatinine, Q3: 1·40-2·96 μg/g creatinine, Q4: >2·96 μg/g creatinine, with the lowest quartile set as reference) with preterm delivery, early-term delivery, low birthweight, and being small for gestational age. We applied restricted cubic spline models to evaluate the dose-response relationships. FINDINGS: Data from 7297 women recruited between Sept 22, 2012, and Oct 22, 2014, were included in this study. Urinary Ln-vanadium concentrations showed no...