A pathology atlas of the human cancer transcriptome

作者：Mathias Uhlén, Cheng Zhang, Sunjae Lee, Evelina Sjöstedt, Linn Fagerberg, Gholamreza Bidkhori, Rui Benfeitas, Muhammad Arif, Zhengtao Liu, Fredrik Edfors, Kemal Sanli, Kalle von Feilitzen, Per Oksvold, Emma K. Lundberg, Sophia Hober, Peter Nilsson, Johanna Sofia Margareta Mattsson, Jochen M. Schwenk, Hans Brunnström, Bengt L. G. Glimelius, Tobias Sjöblom, Per-Henrik D. Edqvist, Dijana Djureinovic, Patrick Micke, Cecilia Lindskog, Adil Mardinoğlu, Fredrik Pontén · 发表于：Science · 年份：2017 · DOI：10.1126/science.aan2507 · 被引用次数：3599 · 研究领域：Cancer Genomics and Diagnostics、RNA modifications and cancer、Gene expression and cancer classification

Cancer is one of the leading causes of death, and there is great interest in understanding the underlying molecular mechanisms involved in the pathogenesis and progression of individual tumors. We used systems-level approaches to analyze the genome-wide transcriptome of the protein-coding genes of 17 major cancer types with respect to clinical outcome. A general pattern emerged: Shorter patient survival was associated with up-regulation of genes involved in cell growth and with down-regulation of genes involved in cellular differentiation. Using genome-scale metabolic models, we show that cancer patients have widespread metabolic heterogeneity, highlighting the need for precise and personalized medicine for cancer treatment. All data are presented in an interactive open-access database (www.proteinatlas.org/pathology) to allow genome-wide exploration of the impact of individual proteins on clinical outcomes.