Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21ststandard: analysis of CHERG datasets

作者：Anne CC Lee, Naoko Kozuki, Simon Cousens, Gretchen A Stevens, Hannah Blencowe, Mariângela Freitas da Silveira, Ayesha Sania, Heather Rosen, Christentze Schmiegelow, Linda S. Adair, Abdullah H Baqui, Fernando C. Barros, Zulfiqar A Bhutta, Laura E. Caulfield, Parul Christian, Siân E. Clarke, Wafaie Fawzi, Rogelio González, Jean H. Humphrey, Lieven Huybregts, Simon Kariuki, Patrick Kolsteren, John Lusingu, Dharma Manandhar, Aroonsri Mongkolchati, Luke C. Mullany, Richard Ndyomugyenyi, Jyh Kae Nien, Dominique Roberfroid, Naomi Saville, Dianne J. Terlouw, James M. Tielsch, César G. Victora, Sithembiso Velaphi, Deborah Watson‐Jones, Barbara Willey, Majid Ezzati, Joy E Lawn, Robert E. Black, Joanne Katz · 发表于：BMJ · 年份：2017 · DOI：10.1136/bmj.j3677 · 被引用次数：391 · 研究领域：Child Nutrition and Water Access、Global Maternal and Child Health、Birth, Development, and Health

Objectives To estimate small for gestational age birth prevalence and attributable neonatal mortality in low and middle income countries with the INTERGROWTH-21st birth weight standard. Design Secondary analysis of data from the Child Health Epidemiology Reference Group (CHERG), including 14 birth cohorts with gestational age, birth weight, and neonatal follow-up. Small for gestational age was defined as infants weighing less than the 10th centile birth weight for gestational age and sex with the multiethnic, INTERGROWTH-21st birth weight standard. Prevalence of small for gestational age and neonatal mortality risk ratios were calculated and pooled among these datasets at the regional level. With available national level data, prevalence of small for gestational age and population attributable fractions of neonatal mortality attributable to small for gestational age were estimated. Setting CHERG birth cohorts from 14 population based sites in low and middle income countries. Main outcome measures In low and middle income countries in the year 2012, the number and proportion of infants born small for gestational age; number and proportion of neonatal deaths attributable to small for gestational age; the number and proportion of neonatal deaths that could be prevented by reducing the prevalence of small for gestational age to 10%. Results In 2012, an estimated 23.3 million infants (uncertainty range 17.6 to 31.9; 19.3% of live births) were born small for gestational age in low ...