Chromosome-Mediated mcr-3 Variants in Aeromonas veronii from Chicken Meat

作者：Zhuoren Ling, Wenjuan Yin, Hui Li, Qidi Zhang, Xiaoming Wang, Zheng Wang, Yuebin Ke, Yang Wang, Jianzhong Shen · 发表于：Antimicrobial Agents and Chemotherapy · 年份：2017 · DOI：10.1128/aac.01272-17 · 被引用次数：83 · 研究领域：Antibiotic Resistance in Bacteria、Vibrio bacteria research studies、Pharmaceutical and Antibiotic Environmental Impacts

ABSTRACT Two adjacent colistin resistance gene variants, termed mcr-3.3 and mcr-3 -like, were identified in the chromosome of an Aeromonas veronii isolate obtained from retail chicken meat. The variants showed 95.20% and 84.19% nucleotide sequence identity, respectively, to mcr-3 from porcine Escherichia coli . Functional cloning indicated that only mcr-3.3 conferred polymyxin resistance in both E. coli and Aeromonas salmonicida . The mcr-3.3-mcr-3 -like segment was also observed in other Aeromonas species, including A. media , A. caviae , and A. hydrophila .