Lactobacillus reuteri induces gut intraepithelial CD4 + CD8αα + T cells

作者：Luisa Cervantes‐Barragán, Jiani Chai, Ma. Diarey B. Tianero, Blanda Di Luccia, Philip P. Ahern, Joseph A. Merriman, Victor S. Cortez, Michael G. Caparon, Mohamed S. Donia, Susan Gilfillan, Marina Cella, Jeffrey I. Gordon, Chyi‐Song Hsieh, Marco Colonna · 发表于：Science · 年份：2017 · DOI：10.1126/science.aah5825 · 被引用次数：902 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Helicobacter pylori-related gastroenterology studies

Tolerogenic T cells need probiotics CD4 + CD8αα + double-positive intraepithelial lymphocytes (DP IELs) are a recently discovered class of intestinal T cells believed to take part in a variety of immune responses, including oral tolerance. These cells are absent in germ-free mice, but the mechanisms driving their development are unclear. Cervantes-Barragan et al. found that a particular species of probiotic bacteria, Lactobacillus reuteri , induces DP IELs. This does not occur by stimulating the immune system directly. Instead, L. reuteri generates a specific derivative of dietary tryptophan that promotes differentiation of DP IEL precursors. These findings underscore the delicate interplay between benign bacteria, diet, and gut health. Science , this issue p. 806