Detection and application of neurochemical profile by multiple regional 1 H‐MRS in Parkinson's disease

作者：Jitian Guan, Rong Yu, Ye Wen, Huanze Wu, Hong Qin, Qingying Zhang, Wei Chen · 发表于：Brain and Behavior · 年份：2017 · DOI：10.1002/brb3.792 · 被引用次数：24 · 研究领域：Parkinson's Disease Mechanisms and Treatments、Advanced MRI Techniques and Applications、Neurological disorders and treatments

Abstract Introduction The accurate diagnosis and monitoring of idiopathic Parkinson disease ( PD ), a progressive neurodegenerative disorder, has not been fully developed. This study sought to identify a neurochemical profile in multiple regions of the PD brain and healthy controls by proton magnetic resonance spectroscopy ( 1 H‐ MRS ). We aimed to track changes of the brain neurochemical, quantify neuronal loss, and further determine the diagnostic value of 1 H‐ MRS . Methods PD patients and healthy controls recruited from Second Affiliated Hospital of Shantou University Medical College, Shantou, southern China, underwent 1 H‐ MRS . Chemical information was obtained for ratios of N‐acetylaspartate to creatine ( NAA /Cr), NAA to choline ( NAA /Cho), and Cho to Cr for substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus, and dorsal thalamus regions. Results Compared to the 20 healthy controls (12 male, age 58.75 ± 5.03 years), the 42 patients (21 male, age 61.60 ± 6.40 years) showed lower NAA /Cr and NAA /Cho ratios in substantia nigra, globus pallidus, prefrontal lobe, hippocampus, cuneus gyrus and dorsal thalamus regions ( p < .01); NAA /Cr and NAA /Cho ratios were reduced for both patients with unilateral and mild/no cognitive impairment ( p < .01); Unified Parkinson's Disease Rating Scale score was inversely correlated with NAA /Cr ratios in the substantia nigra ( r = −.32; p = .042). Conclusion NAA /Cr and NAA /Cho ratios may be useful metab...