Higher incidence rates than previously known in tenosynovial giant cell tumors

作者：M.J.L. Mastboom, F.G.M. Verspoor, Arie J. Verschoor, Daniël Uittenbogaard, Banne Nemeth, W. J. B. Mastboom, Judith V.M.G. Bovée, P. D. S. Dijkstra, H.W.B. Schreuder, Hans Gelderblom, Michiel A. J. van de Sande, TGCT study group · 发表于：Acta Orthopaedica · 年份：2017 · DOI：10.1080/17453674.2017.1361126 · 被引用次数：155 · 研究领域：Musculoskeletal synovial abnormalities and treatments、Tendon Structure and Treatment、Plant and Fungal Interactions Research

Background and purpose - Tenosynovial giant cell tumors (TGCT) are rare, benign tumors, arising in synovial lining of joints, tendon sheaths, or bursae. 2 types are distinguished: localized, either digits or extremity, and diffuse lesions. Current TGCT incidence is based on 1 single US-county study in 1980, with an incidence of 9 and 2 per million person-years in localized (including digits) and diffuse TGCT, respectively. We aim to determine nationwide and worldwide incidence rates (IR) in TGCT affecting digits, localized-extremity TGCT and diffuse-type TGCT. Material and methods - Over a 5-year period, the Dutch Pathology Registry (PALGA) identified 4,503 pathology reports on TGCT. Reports affecting digits were solely used for IR calculations. Reports affecting extremities were clinically evaluated. Dutch IRs were converted to world population IRs. Results - 2,815 (68%) digits, 933 (23%) localized-extremity and 390 (9%) diffuse-type TGCT were identified. Dutch IR in digits, localized-extremity, and diffuse-type TGCT was 34, 11 and 5 per million person-years, respectively. All 3 groups showed a female predilection and highest number of new cases in age category 40-59 years. The knee joint was most often affected: localized-extremity (46%) and diffuse-type (64%) TGCT, mostly treated with open resection: localized (65%) and diffuse (49%). Reoperation rate due to local recurrence for localized-extremity was 9%, and diffuse TGCT 23%. Interpretation - This first nationwide study ...