Calcium influx and sperm-evoked calcium responses during oocyte maturation and egg activation

作者：Yaru Xu, Wan‐Xi Yang · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.19679 · 被引用次数：22 · 研究领域：Reproductive Biology and Fertility、Sperm and Testicular Function、Seed Germination and Physiology

// Ya-Ru Xu 1 and Wan-Xi Yang 1 1 The Sperm Laboratory, College of Life Sciences, Zhejiang University, Hangzhou, China Correspondence to: Wan-Xi Yang, email: // Keywords : oocyte maturation, calcium influx, egg activation, calcium oscillation, calcium response Received : May 09, 2017 Accepted : June 19, 2017 Published : July 29, 2017 Abstract Under the guidance and regulation of hormone signaling, large majority of mammalian oocytes go through twice cell cycle arrest-resumption prior to the fertilized egg splits: oocyte maturation and egg activation. Cytosolic free calcium elevations and endoplasmic reticulum calcium store alternations are actively involved in triggering the complex machineries and events during oogenesis. Among these, calcium influx had been implicated in the replenishment of endoplasmic reticulum store during oocyte maturation and calcium oscillation during egg activation. This process also drove successful fertilization and early embryo development. Store-operated Ca 2+ entry, acts as the principal force of calcium influx, is composed of STIM1 and Orai1 on the plasma membrane. Besides, transient receptor potential channels also participate in the process of calcium inwards. In this review, we summarize the recent researches on the spatial-temporal distribution of store-operated calcium entry components and transient receptor potential channels. Questions about how these channels play function for calcium influx and what impacts these channels have on oocyt...