Plasmonic silver nanoshells for drug and metabolite detection

作者：Lin Huang, Jingjing Wan, Xiang Wei, Yu Liu, Jingyi Huang, Xuming Sun, Ru Zhang, Deepanjali D. Gurav, Vadanasundari Vedarethinam, Yan Li, Ruoping Chen, Kun Qian · 发表于：Nature Communications · 年份：2017 · DOI：10.1038/s41467-017-00220-4 · 被引用次数：210 · 研究领域：Mass Spectrometry Techniques and Applications、Gold and Silver Nanoparticles Synthesis and Applications、Biosensors and Analytical Detection

@Ag with tunable shell structures by multi-cycled silver mirror reactions. Optimized nanoshells achieved direct laser desorption/ionization mass spectrometry in 0.5 μL of bio-fluids. We applied these nanoshells for disease diagnosis and therapeutic evaluation. We identified patients with postoperative brain infection through daily monitoring and glucose quantitation in cerebrospinal fluid. We measured drug distribution in blood and cerebrospinal fluid systems and validated the function of blood-brain/cerebrospinal fluid-barriers for pharmacokinetics. Our work sheds light on the design of materials for advanced metabolic analysis and precision diagnostics.Preparation of samples for diagnosis can affect the detection of biomarkers and metabolites. Here, the authors use a silver nanoparticle plasmonics approach for the detection of biomarkers in patients as well as investigate the distribution of drugs in serum and cerebral spinal fluid.