The drug transporter OAT3 (SLC22A8) and endogenous metabolite communication via the gut–liver–kidney axis

作者：Kevin T. Bush, Wei Wu, Christina Lun, Sanjay K. Nigám · 发表于：Journal of Biological Chemistry · 年份：2017 · DOI：10.1074/jbc.m117.796516 · 被引用次数：107 · 研究领域：Drug Transport and Resistance Mechanisms、Pharmacogenetics and Drug Metabolism、Pharmacological Effects and Toxicity Studies

bile acids). Furthermore, the metabolomics and pathway analysis support the view that OAT1 plays a greater role in kidney proximal tubule metabolism and OAT3 appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney.