MiR-590-3p promotes proliferation and metastasis of colorectal cancer via Hippo pathway

作者：Zhenqiang Sun, Ke Shi, Quanbo Zhou, Xiangyue Zeng, Jinbo Liu, Shuaixi Yang, Qisan Wang, Zhen Li, Guixian Wang, Junmin Song, Weitang Yuan, Haijiang Wang · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.19487 · 被引用次数：42 · 研究领域：Hippo pathway signaling and YAP/TAZ、Wnt/β-catenin signaling in development and cancer、Cancer-related Molecular Pathways

// Zhen-Qiang Sun 1, 2, * , Ke Shi 3, * , Quan-Bo Zhou 1, * , Xiang-Yue Zeng 2 , Jinbo Liu 1 , Shuai-Xi Yang 1 , Qi-San Wang 2 , Zhen Li 1 , Gui-Xian Wang 1 , Jun-Min Song 1 , Wei-Tang Yuan 1 and Hai-Jiang Wang 1, 2 1 Department of Anorectal Surgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China 2 Department of Gastrointestinal Surgery, Affiliated Tumor Hospital, Xinjiang Medical University, Urumqi 830011, China 3 Department of Orthopedic Surgery, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China * These authors have contributed equally to this work Correspondence to: Zhen-Qiang Sun, email: zqsun82@csu.edu.cn Wei-Tang Yuan, email: yuanweitang@zzu.edu.cn Hai-Jiang Wang, email: wanghaijiang@medmail.com.cn Keywords: miR-590-3p, colorectal cancer, Hippo pathway, proliferation, metastasis Received: April 28, 2017 Accepted: June 19, 2017 Published: July 22, 2017 ABSTRACT Studies reported that miR-590-3p was involved in human cancer progression. However, its roles of oncogene or anti-oncogene in malignancies still remain elusive. This study was aimed to investigate the effect of miR-590-3p on the cell proliferation and metastasis via Hippo pathway in colorectal cancer (CRC). In our study, miR-590-3p was demonstrated highly expressed in CRC tissues, compared with adjacent normal tissues ( P <0.05). In addition, miR-590-3p was positively associated with TNM stage and distant metastasis. Survival analysis showed that high miR-590-3p was...