Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments

作者：Chen Chen, Haifeng Zhang, Hongliang Xu, Yake Zheng, Tianwen Wu, Yajun Lian · 发表于：Journal of Ginseng Research · 年份：2017 · DOI：10.1016/j.jgr.2017.07.009 · 被引用次数：75 · 研究领域：Cancer-related cognitive impairment studies、Ginseng Biological Effects and Applications、Chemotherapy-induced organ toxicity mitigation

BACKGROUND: root, exhibits neuroprotective functions in many neurological diseases. This study was intended to investigate whether Rb1 can attenuate cisplatin-induced memory impairments and explore the potential mechanisms. METHODS: Cisplatin was injected intraperitoneally with a dose of 5 mg/kg/wk, and Rb1 was administered in drinking water at the dose of 2 mg/kg/d to rats for 5 consecutive wk. The novel objects recognition task and Morris water maze were used to detect the memory of rats. Nissl staining was used to examine the neuron numbers in the hippocampus. The activities of superoxide dismutase, glutathione peroxidase, cholineacetyltransferase, acetylcholinesterase, and the levels of malondialdehyde, reactive oxygen species, acetylcholine, tumor necrosis factor-α, interleukin-1β, and interleukin-10 were measured by ELISA to assay the oxidative stress, cholinergic function, and neuroinflammation in the hippocampus. RESULTS: Rb1 administration effectively ameliorates the memory impairments caused by cisplatin in both novel objects recognition task and Morris water maze task. Rb1 also attenuates the neuronal loss induced by cisplatin in the different regions (CA1, CA3, and dentate gyrus) of the hippocampus. Meanwhile, Rb1 is able to rescue the cholinergic neuron function, inhibit the oxidative stress and neuroinflammation in cisplatin-induced rat brain. CONCLUSION: Rb1 rescues the cisplatin-induced memory impairment via restoring the neuronal loss by reducing oxidative st...