Treatments for Idiopathic Granulomatous Mastitis: Systematic Review and Meta-Analysis

作者：Lei Xin, Kai Chen, Liling Zhu, Erwei Song, Fengxi Su, Shunrong Li · 发表于：Breastfeeding Medicine · 年份：2017 · DOI：10.1089/bfm.2017.0030 · 被引用次数：147 · 研究领域：Breast Lesions and Carcinomas、Breast Implant and Reconstruction、Metastasis and carcinoma case studies

OBJECTIVES: Idiopathic granulomatous mastitis (IGM) is a benign breast disease with no ideal treatment regimen so far. This study aimed to evaluate the complete remission/resolution (CR) rate and recurrence rate of different treatment options. METHODS: We systematically searched and identified eligible studies from January 1, 2010, to December 31, 2015, in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Medline databases. We included original studies reporting the CR and/or recurrence rate of each treatment used. The pooled incidence and 95% confidence interval (95% CI) for CR and recurrence rate were calculated using Stata 13.0. RESULTS: Fifteen eligible studies were included in our study. Six, nine, and five studies with 138, 358, and 106 patients were analyzed for surgical managements, oral steroids, and oral steroids+surgical managements, respectively. The pooled estimates for CR rate of them were 90.6% (95% CI 83.8%, 95.7%), 71.8% (95% CI 67.1%, 76.3%), and 94.5% (95% CI 88.9%, 98.3%). The pooled estimates for recurrence rate were 6.8% (95% CI 3.3%, 11.5%), 20.9% (95% CI 9.2%, 16.1%), and 4.0% (95% CI 1.5%, 8.4%), respectively. Other interventions analyzed were topical steroids, observation, oral steroids+MTX, and steroids+prolactin lowering agent, with varied pooled estimates for CR and recurrence rate. CONCLUSION: Surgical managements had high CR rate with relatively low recurrence rate, with or without steroids. Thus, it was suitable for patients r...