Alkyne Hydroheteroarylation: Enantioselective Coupling of Indoles and Alkynes via Rh-Hydride Catalysis

作者：Faben A. Cruz, Yamin Zhu, Quentin D. Tercenio, Zengming Shen, Vy M. Dong · 发表于：Journal of the American Chemical Society · 年份：2017 · DOI：10.1021/jacs.7b05893 · 被引用次数：111 · 研究领域：Catalytic C–H Functionalization Methods、Asymmetric Hydrogenation and Catalysis、Catalytic Alkyne Reactions

We report an enantioselective coupling between alkynes and indoles. A Rh-hydride catalyst isomerizes alkynes to generate a metal-allyl species that can be trapped with both aromatic and heteroaromatic nucleophiles.