Silencing PPA1 inhibits human epithelial ovarian cancer metastasis by suppressing the Wnt/β-catenin signaling pathway

作者：Haiying Niu, Wei Zhou, Yingxi Xu, Zhi‐Qi Yin, Wenzhi Shen, Zhen Ye, Yanhua Liu, Yanan Chen, Shuang Yang, Rong Xiang, Lina Wang, Pengpeng Qu · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.19346 · 被引用次数：24 · 研究领域：RNA modifications and cancer、Adenosine and Purinergic Signaling、Wnt/β-catenin signaling in development and cancer

// Haiying Niu 1, * , Wei Zhou 2, * , Yingxi Xu 3 , Zhiqi Yin 4 , Wenzhi Shen 2 , Zhen Ye 2 , Yanhua Liu 2 , Yanan Chen 2 , Shuang Yang 2 , Rong Xiang 2 , Lina Wang 3 and Pengpeng Qu 5 1 Department of Gynecology and Obstetrics, Tianjin First Center Hospital, Tianjin, China 2 Department of Immunology, Nankai University School of Medicine, Tianjin, China 3 State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Disease Hospital, Chinese Academy of Medical Sciences, Tianjin, China 4 Department of Pathology, Tianjin First Center Hospital, Tianjin, China 5 Department of Gynecology Oncology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin, China * These authors have contributed equally to this work Correspondence to: Lina Wang, email: wanglina@ihcams.ac.cn Pengpeng Qu, email: qu.pengpeng@hotmail.com Keywords: PPA1, epithelial ovarian cancer, metastasis, Wnt/β-catenin Received: January 18, 2017     Accepted: June 19, 2017     Published: July 18, 2017 ABSTRACT Inorganic pyrophosphatase (PPA1) activity is a key determinant of cellular inorganic pyrophosphate levels, and its expression is correlated with growth of several solid tumors. To investigate this relationship, we first examined PPA1 expression in human epithelial ovarian cancer (EOC) samples, and found that PPA1 was overexpressed in tumors from EOC patients. Higher PPA1 levels correlated with advanced grades, stages, and poor survival in EOC pat...