Association of Ozone Exposure With Cardiorespiratory Pathophysiologic Mechanisms in Healthy Adults

作者：Drew B. Day, Jianbang Xiang, Jinhan Mo, Feng Li, Ming Kei Chung, Jicheng Gong, Charles J. Weschler, Pamela Ohman‐Strickland, Jan Sundell, Wenguo Weng, Yinping Zhang, Junfeng Zhang · 发表于：JAMA Internal Medicine · 年份：2017 · DOI：10.1001/jamainternmed.2017.2842 · 被引用次数：272 · 研究领域：Air Quality and Health Impacts、Indoor Air Quality and Microbial Exposure、Climate Change and Health Impacts

Importance: Exposure to ozone has been associated with cardiovascular mortality, but the underlying biological mechanisms are not yet understood. Objective: To examine the association between ozone exposure and cardiopulmonary pathophysiologic mechanisms. Design, Setting, and Participants: A longitudinal study involving 89 healthy adult participants living on a work campus in Changsha City, China, was conducted from December 1, 2014, to January 31, 2015. This unique quasiexperimental setting allowed for better characterization of air pollutant exposure effects because the participants spent most of their time in controlled indoor environments. Concentrations of indoor and outdoor ozone, along with the copollutants particulate matter, nitrogen dioxide, and sulfur dioxide, were monitored throughout the study period and then combined with time-activity information and filtration conditions of each residence and office to estimate 24-hour and 2-week combined indoor and outdoor mean exposure concentrations. Associations between each exposure measure and outcome measure were analyzed using single-pollutant and 2-pollutant linear mixed models controlling for ambient temperature, secondhand smoke exposure, and personal-level time-varying covariates. Main Outcomes and Measures: Biomarkers indicative of inflammation and oxidative stress, arterial stiffness, blood pressure, thrombotic factors, and spirometry were measured at 4 sessions. Results: Of the 89 participants, 25 (28%) were wom...