httk : R Package for High-Throughput Toxicokinetics

作者：Robert G. Pearce, R. Woodrow Setzer, Cory L Strope, Nisha S. Sipes, John F. Wambaugh · 发表于：Journal of Statistical Software · 年份：2017 · DOI：10.18637/jss.v079.i04 · 被引用次数：320 · 研究领域：Computational Drug Discovery Methods、Animal testing and alternatives、Effects and risks of endocrine disrupting chemicals

Thousands of chemicals have been profiled by high-throughput screening programs such as ToxCast and Tox21; these chemicals are tested in part because most of them have limited or no data on hazard, exposure, or toxicokinetics. Toxicokinetic models aid in predicting tissue concentrations resulting from chemical exposure, and a