RutA-Catalyzed Oxidative Cleavage of the Uracil Amide Involves Formation of a Flavin-N5-oxide

作者：Sanjoy Adak, Tadhg P. Begley · 发表于：Biochemistry · 年份：2017 · DOI：10.1021/acs.biochem.7b00493 · 被引用次数：53 · 研究领域：Catalytic C–H Functionalization Methods、Chemical Synthesis and Analysis、Fluorine in Organic Chemistry

RutA is a novel flavoenzyme on the uracil catabolic pathway that catalyzes uracil ring opening by a unique amide oxidation reaction. Here we provide evidence that this reaction also involves the formation of a flavin-N5-oxide.