PLD1 overexpression promotes invasion and migration and function as a risk factor for Chinese glioma patients

作者：Wenjun Tang, Richu Liang, Yonghong Duan, Qiaoling Shi, Xiaofei Liu, Yongshi Liao · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.18961 · 被引用次数：9 · 研究领域：Cancer, Lipids, and Metabolism、RNA modifications and cancer、Ferroptosis and cancer prognosis

// Wenjun Tang 1, * , Richu Liang 1, * , Yonghong Duan 1 , Qiaoling Shi 1 , Xiaofei Liu 1 and Yongshi Liao 1 1 Department of Neurosurgery, The Second Hospital Affiliated to University of South China, Hengyang, Hunan, 421000 China * These authors contributed equally to this work Correspondence to: Yongshi Liao, email: Twj120797968@163.com Keywords: PLD1, glioma, prognosis, invasion, migration Received: January 16, 2017      Accepted: June 18, 2017      Published: July 05, 2017 ABSTRACT Glioma is a lethal disease with few effective therapeutic options. Recently, insights into cancer biology had suggested that abnormal lipid metabolism was a risk factor for various human malignancies, including glioma. As a key enzyme implicated in lipid metabolism, PLD1 was overexpression in multiple human cancers, and it was stated to be responsible for aggressive phenotypes, such as angiogenesis and chemoresistance. However, there was still much to know about its expression and function in glioma. In the present study, we showed that PLD1 was overexpression in clinical samples of glioma. In addition, the correlation assay revealed that PLD1 overexpression was correlated with poor differentiation ( p = 0.04), and it was responsible for a poor prognosis for the patients ( p = 0.009). Furthermore, we showed in COX regression assay that PLD1 was a risk factor for glioma ( p = 0.018, HR = 0.461, 95% CI = 0.243–0.887). Consistently, we found t...