Additional N-glycosylation mutation in the major hydrophilic region of hepatitis B virus S gene is a risk indicator for hepatocellular carcinoma occurrence in patients with coexistence of HBsAg/anti-HBs

作者：Yan Qiao, Shanshan Lu, Zhihui Xu, Xiaodong Li, Kai Zhang, Yan Liu, Li Zhao, Rongjuan Chen, Lanlan Si, Shumei Lin, Dongping Xu, Jin Li · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.18682 · 被引用次数：24 · 研究领域：Hepatitis B Virus Studies、Hepatitis C virus research、Liver Disease Diagnosis and Treatment

// Yan Qiao 1, 2, * , Shanshan Lu 1, * , Zhihui Xu 1, * , Xiaodong Li 1 , Kai Zhang 1, 4 ,Yan Liu 1 , Li Zhao 1 , Rongjuan Chen 1 , Lanlan Si 1 , Shumei Lin 4 , Dongping Xu 1, 2 and Jin Li 1, 3 1 Research Center for Clinical and Translational Medicine/Institute of Infectious Diseases, Beijing 302 Hospital, Beijing 100039, China 2 Clinical Medical School, Guilin Medical University, Guilin 541004, China 3 Medical Department, Beijing 302 Hospital, Beijing 100039, China 4 Department of Infectious Disease, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China * These authors have contributed equally to this work Correspondence to: Dongping Xu, email: xudongping302@sina.com Jin Li, email: lijin302@hotmail.com Keywords: hepatitis B virus, mutation, additional N-glycosylation, HBsAg/anti-HBs coexistence, hepatocellular carcinoma Received: December 22, 2016     Accepted: May 08, 2017     Published: June 27, 2017 ABSTRACT The study aimed to determine the association of additional N-glycosylation mutations in the major hydrophilic region (MHR) of hepatitis B virus (HBV) S gene with hepatocellular carcinoma (HCC) occurrence in HBsAg/anti-HBs coexistent patients. A total of 288 HBsAg/anti-HBs coexistent patients and 490 single HBsAg-positive patients were enrolled, including 193 with HCC, 433 with chronic hepatitis B (CHB), and 152 with acute-on-chronic liver failure (ACLF). The HBV S genes were amplified from serum...