Regulatory 3′ Untranslated Regions of Bacterial mRNAs

作者：Gaixian Ren, Xiao-Peng Guo, Yicheng Sun · 发表于：Frontiers in Microbiology · 年份：2017 · DOI：10.3389/fmicb.2017.01276 · 被引用次数：39 · 研究领域：RNA and protein synthesis mechanisms、Bacterial Genetics and Biotechnology、Bacteriophages and microbial interactions

The untranslated regions (UTRs) of mRNA contain important features that are relevant to the post-transcriptional and translational regulation of gene expression. Most studies of bacterial UTRs have focused on the 5'regions; however, 3'UTRs have recently emerged as a new class of post-transcriptional regulatory elements. 3'UTRs were found to regulate the decay and translation initiation in their own mRNAs. In addition, 3'UTRs constitute a rich reservoir of small regulatory RNAs, regulating target gene expression. In the current review, we describe several recently discovered examples of bacterial regulatory 3'UTRs, discuss their modes of action, and illustrate how they facilitate gene regulation in various environments.