Cobalt(II)-Catalyzed Isocyanide Insertion Reaction with Sulfonyl Azides in Alcohols: Synthesis of Sulfonyl Isoureas

作者：Tian Jiang, Zheng‐Yang Gu, Ling Yin, Shun‐Yi Wang, Shun‐Jun Ji · 发表于：The Journal of Organic Chemistry · 年份：2017 · DOI：10.1021/acs.joc.7b01127 · 被引用次数：34 · 研究领域：Catalytic C–H Functionalization Methods、Synthesis and Catalytic Reactions、Sulfur-Based Synthesis Techniques

A Co(II)-catalyzed isocyanide insertion reaction with sulfonyl azides in alcohols to form sulfonyl isoureas via nitrene intermediate has been developed. This protocol provides a new, environmentally friendly, and simple strategy for the synthesis of sulfonyl isourea derivatives by employing a range of substrates under mild conditions.