B7-H4 as an independent prognostic indicator of cancer patients: a meta-analysis

作者：Zibo Meng, Feiyang Wang, Yushun Zhang, Shoukang Li, Heshui Wu · 发表于：Oncotarget · 年份：2017 · DOI：10.18632/oncotarget.18566 · 被引用次数：13 · 研究领域：Radiomics and Machine Learning in Medical Imaging、Medical Imaging Techniques and Applications、Cancer Immunotherapy and Biomarkers

// Zibo Meng 1, * , Feiyang Wang 1, * , Yushun Zhang 1 , Shoukang Li 1 and Heshui Wu 1 1 Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China * These authors contribute equally to this work Correspondence to: Heshui Wu, email: heshuiwu@hust.edu.cn Keywords: B7-H4, cancer, prognosis, meta-analysis Received: May 09, 2017      Accepted: June 11, 2017      Published: June 19, 2017 ABSTRACT The expression of B7-H4 was observed in a variety of tumors, however the prognostic value in cancer was still controversial. Therefore, we conducted this meta-analysis to explore the potential role of B7-H4 in cancer prognostic prediction. Twenty-seven studies including 3771 patients were brought into the analysis according to the inclusion and exclusion criteria. The pooled results demonstrated that elevated B7-H4 predicted a poor OS (HR = 1.93, 95% CI 1.71-2.18, P < 0.001) and DFS (HR = 1.84, 95% CI 1.46-2.33, P < 0.001). Subgroup analysis showed that races, tumor types, sample sources, analysis types, sources of HR and sample sizes exhibited non-significant distinctions with OS (P S = 0.878, P S = 0.143, P S = 0.613, P S = 0.639, P S = 0.48 and P S = 0.528, respectively). PubMed, Embase and the Cochrane Library were searched up to April 7, 2017, to recognize the available studies for assessing the association between B7-H4 and cancer patients’ ...