Metabolic Origins of Heart Failure

作者：Adam R. Wende, Manoja K. Brahma, Graham R. McGinnis, Martin E. Young · 发表于：JACC Basic to Translational Science · 年份：2017 · DOI：10.1016/j.jacbts.2016.11.009 · 被引用次数：215 · 研究领域：Diet and metabolism studies、Metabolism and Genetic Disorders、Cardiovascular Function and Risk Factors

For more than half a century, metabolic perturbations have been explored in the failing myocardium, highlighting a reversion to a more fetal-like metabolic profile (characterized by depressed fatty acid oxidation and concomitant increased reliance on glucose utilization). More recently, alterations in ketone body and amino acid/protein metabolism have been described during heart failure, as well as mitochondrial dysfunction and perturbed metabolic signaling (e.g., acetylation, O-GlcNAcylation). Although numerous mechanisms are likely involved, the current review provides recent advances regarding the metabolic origins of heart failure, and their potential contribution toward contractile dysfunction of the heart.