The long noncoding RNA Wisper controls cardiac fibrosis and remodeling

作者：Rudi Micheletti, Isabelle Plaisance, Brian J. Abraham, Alexandre Sarre, Ching-Chia Ting, Michael Alexanian, Daniel Maric, Damien Maison, Mohamed Nemir, Richard A. Young, Blanche Schroen, Arantxa González, Samir Ounzain, Thierry Pedrazzini · 发表于：Science Translational Medicine · 年份：2017 · DOI：10.1126/scitranslmed.aai9118 · 被引用次数：346 · 研究领域：Cancer-related molecular mechanisms research、Cardiac Valve Diseases and Treatments、Cardiac Fibrosis and Remodeling

as a cardiac fibroblast-enriched super-enhancer-associated lncRNA that represents an attractive therapeutic target to reduce the pathological development of cardiac fibrosis in response to MI and prevent adverse remodeling in the damaged heart.